University of Louisville Bioinformatics

The mission of the University of Louisville Bioinformatics Laboratory is threefold: 1) Further advance the interdisciplinary field of bioinformatics by conducting internationally recognized bioinformatics research in the broad areas of DNA and protein sequence analysis. 2) Provide graduate-level bioinformatics educational training to produce graduates competitive at the regional, national, and international levels. 3) Contribute to the bioinformatics growth in the Commonwealth of Kentucky through active participation in the Kentucky Biomedical Research Infrastructure Network (KBRIN) and the Kentucky Academy of Sciences (KAS).

The primary areas of interest for the bioinformatics lab are: Computational analysis of gene regulatory regions; Variability and tissue specificity of gene products; Detection and classification of non-functional pseudogenes; DNA computing for enhanced security; High throughput bioinformatics computation using general purpose graphics processor units (GPGPUs).

http://bioinformatics.louisville.edu/lab/

The Cardinal Research Cluster (CRC) includes a high-performance distributed-memory cluster, a high-memory SMP machine, an informatics data management system, a visualization server, and other support servers. The distributed-memory cluster has 312 IBM iDataplex nodes with a total of 2496 processor cores. The SMP machine has 16 IBM Power6 CPUs and 128 GB of memory. The visualization server contains two quad-core AMD Opteron processors and an nVidia Quadro FX5600 graphics processing unit with 128 processor cores. The Informatics data management system has 20 TB of dedicated storage and is optimized for transaction processing in Oracle along with provided MySQL database management systems. All research systems share 100 TB of data storage and archiving space. All the systems are housed in the University's secure data center and are be administered by a team of specialized HPC system administrators supported by a team of research computing consultants with experience in HPC software and database design, development and optimization.

http://louisville.edu/it/research/

The Mission of the Data Mining Lab is: To conduct advanced research in data mining and knowledge discovery for business, government and scientific needs; to support graduate academic program in data mining and knowledge discovery; to better equip students for the workplace by providing training in different aspects of the data mining cycle; to help businesses and government agencies understand the concepts and advantages of data mining by conduction proof-of-performance data mining projects; to be a clearinghouse for advanced data mining technologies by providing an objective comparison of the strengths, weaknesses, and capabilities of different tools and technologies; and to provide training for industry management and practioners in data mining.

http://www.louisville.edu/~mmkant01/dmlab/index.html

Databases (especially query languages, data models, metadata, conceptual modeling, heterogeneous information integration, data warehousing, cooperative query answering), applied logic, artificial intelligence (especially knowledge representation, ontologies, case-based reasoning, natural language processing), and everything that mixes two or more of the above, like Information Extraction (IE) and Question Answering (QA).

http://date.spd.louisville.edu/DBLab/

The KyBRIN Bioinformatics Cluster is a 16-node, 32-CPU Dual AMD 2400 Beowulf cluster computer running SUSE Linux 10.0. Use of the cluster is intended for researchers and students throughout the Kentucky Biomedical Research Infrastructure Network (KBRIN) in order to further the development of bioinformatics education and research. The cluster is currently located at the Dahlem Supercomputer Center at the University of Louisville Speed School of Engineering.

The 117,000 square foot Belknap Research Building, which opened in 2006, features a 10,000 ft² cleanroom core facility used primarily to fabricate, package, and test various microelectronic devices and circuits. The Building houses scientists from the College of Arts and Sciences, Speed School of Engineering, and Health Sciences Center.

The goal of KBRIN is to develop a network of support for biomedical researchers and educators within the Commonwealth of Kentucky. The purpose of the network is to develop infrastructure and capacity for biomedical research and training in the state.

http://www.kbrin.louisville.edu/

The mission of the Center for Genetics in Molecular Medicine is to: Provide the focus for research, training, and services in genetics and molecular medicine at the University of Louisville; Enhance scientific training of undergraduate and graduate students, medical students, postdoctoral fellows and clinical residents in the area of genetics and molecular medicine; Provide a forum for information exchange relevant to genetics and increase the number of university faculty using molecular genetic approaches to research.

http://www.louisville.edu/medschool/genetics/

The University of Louisville Core Proteomics Laboratory was established in 1997. Through generous funding from the Commonwealth of Kentucky, a state of the art, high through-put proteomics facility opened September 1999 in the new Donald E. Baxter Research Building. The UofL Proteomics Laboratory is a core technology facility for the University of Louisville and the Commonwealth of Kentucky. Directed by the University of Louisville Kidney Disease Program.

http://kdpnw.kdp-baptist.louisville.edu/proteomelab/

The Microarray Facility of the Brown Cancer Center in Louisville, KY, provides gene expression analysis and genotyping services using the Affymetrix Genechip(R) system. A Nanodrop ND-1000 spectrophotometer is now available in the BCC.

http://www.louisville.edu/medschool/medicine/microarray/index.htm

The Mission of the Biomolecular Mass Spectrometry Core Laboratory is to: Promote and develop the use of mass spectrometry as a research tool within the UofL; Participate in the development of and potentiation of the research activities of Centers, Institutes and other organized research groups; Participate in research collaborations and provide service to as many individuals as possible within the UofL research community; Provide exposure to mass spectrometry to graduate and undergraduate students of the UofL; Assist members of the UofL research community in seeking and sustaining funding from extramural sponsors

http://www.louisville.edu/~wmpier01/biomassspec.htm

The nucleic acids core provides DNA sequencing, genotyping, and microarray services to the University of Louisville investigators.

http://www.dna.louisville.edu/