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| I am an associate professor in the Computer Engineering and Computer Science (CECS) Department at the University of Louisville. My current research interests include: Computer Graphics, Bioinformatics, Databases and Internet Applications. |
| Ph.D. in Anatomy and Neurobiology, University of Tennessee Health Sciences Center. Current research interests include neuronal cell death in models of neurodegeneration that may be useful aids for the development of neurotherapeutic agents. In our laboratory we are developing and testing a gene-array containing a set of cell death-related genes. This cell death biochip will be used to determine the signal transduction pathways that operate between the stimulus and the ultimate response that is cell death. This gene-array can then also be used to determine the effectiveness of agents that could interrupt such pathways, thereby, protecting neurons in time of stress. Collaborators include faculty and students in CECS who helping us to develop the tools needed to design and analyze custom gene-arrays and to automate these processes. |
| Research Interests: Bioinformatics, Infectious Disease Modeling, Inference, Statistical Genetics, Statistical issues in Population Biology, Survival Analysis. |
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Qiang He Information Here |
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Thomas Knudsen Information Here |
| Currently, I am a visiting professor at the University of Louisville splitting my time evenly between the Department of Computer Engineering and Computer Science and the Health Sciences Campus. The current interest in bioinformatics and computational biology at the University of Louisville are applications directly related to microarrays, including efficient primer design, microarray image analysis, and database design. My personal interests lie in the area of DNA sequence analysis. Among the topics present and past that I have worked on include: primer design, microarray analysis, genomic segmentation, contig assembly, sequence assembly validation, location of large scale polymorphic sites, single nucleotide polymorphism (SNP) analysis, repeat analysis, genomic evolution, and sequence motif detection. | |
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I strongly believe that future progress and understanding of the biological sciences at systems level will depend upon effective management of proliferating data and creation of new integrated knowledge base. Much of the biology of tomorrow will arise through discovery based on information contained in community-accessible databases and future progress will be highly dependent on the ability of the scientific community to acquire, store and retrieve not only biological research data, but also those data in the context of biological knowledge base. Currently I am working as a Research Scientist at the Systems Analysis Laboratory at University of Louisville. My current interest in bioinformatics and computational biology at the University of Louisville are Database design; Heterogeneous Database Integration, Visualization, Microarray Data Analysis and Development of Knowledge base. |
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Yizhi Zhang Information Here |
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STUDENTS |
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Ms. Cha is a doctoral student in Computer Science and Engineering (CSE) at the University of Louisville. She also has a B.S. degree in Chemistry and a M.S. in Computer Science. Her research interest is in the area of algorithms for sequence alignments and clustering of Expressed Sequences Tags (ESTs) in Bioinformatics. |
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Mr. Hardin received his B.S. in Industrial Engineering from the University of Oklahoma, and spent many years in industry and finance. In 2001, he returned to academia at the University of Louisville where he received an M.S. in Computer Engineering and Computer Science. He is currently pursuing a Ph.D. in Computer Science and Engineering and teaching undergraduate courses in Computer Science. His research interests are simulation and swarm intelligence. His current research project is the application of heuristic algorithms to motif discovery in DNA sequences. |
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Recent Graduates |
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| Heejun Choi | Dr. Choi completed his PhD and has returned to his home in Korea. His dissertation involved software for the analysis of midroarray data. SmartArray has three tools: a template alignment tool, a quantification tool, and an analysis tool. The processing and analysis are performed sequentially regardless of the type of microarray images. First, scanned microarray images are corrected in the preprocessing step if they are tilted. Then, circle templates are placed on the spots in microarray images using MCF (Microarray Configuration File) files, and the spots are quantified by user-defined methods. Finally, the gene expression data from a control microarray and a test microarray is compared and analyzed for gene analysis. |
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Dr. Cui defended his disertation in December of 2004, and has accepted a post-doctoral fellowship at Oak Ridge National Labs, in Oak Ridge, Tennessee. His dissertation was in the area of intelligent agents and collective intelligence. In the area of bioinformatics, he convereted programs and algorithms from single processor execution high performance parallel applications. |
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Mr. Hornsby recieved his M.Eng. degree in the Spring of 2005 from the University of Louisville. His thesis topic was in the area of developing on-line database storage and processing of microarray data. |
